Microarray Chips and Microarray Analysis

Microarray analysis encompasses the fabrication and application of microarray chips. Unlike DNA sequencing and genotyping, the analytes for different types of microarrays gene expression analysis are messenger RNAs. Messenger RNAs are much more unstable than RNA and require stringent handling protocols to prevent artifacts caused by degradation by RNase enzymes. In most microarray analyses, complementary DNA (cDNA) is generated via reverse transcription.

Ⅰ. Microarrays for Cytogenetic Analysis

1. Cytogenetic Analysis via Microarray Detection

Complete microarray chips and kits for genome-wide analysis. Microarrays are commonly used to detect structural variations and accurately characterize chromosomal aberrations that lead to disease. These arrays and kits provide robust, reliable low- and high-throughput processing methods.

2. Cytogenetics Suite Provides Balanced Genome-Wide Coverage

Cytogenetics Kit arrays provide an optimal balance of polymorphic and non-polymorphic probes compared to other probes that lack the ability to obtain true balanced genome-wide coverage due to limitations in probe density, reproducibility, and placement , for comprehensive coverage of cytogenetics applications.

Ⅱ. Microarrays for Transcriptome Profiling

Phenotypic abnormalities rarely result form changes in the expression of a single gene, thus, generating comprehensive expression profiles is critical for studying normal biological and disease processes. In addition, important expression changes, such as differential exon usage due to alternative splicing events, may be masked in gene-level profiling. Microarrays offer the great advantage of detecting millions of different sequences simultaneously, making the technology robust against challenges encountered when detecting and measuring low-abundance transcripts or rare alternative splicing events.

Microarrays and associated assarys provide broad coverage of coding and non-coding genes with arrays and assays designed to measure the 3' end of the poly-A component of the transcriptome, as well as transcript-wide assays and arrays designed to cover all transcribed exons across a gene.

Whole-transcript profiling methods allow researchers to examine not only expression levels but also expression content-including alternative isoforms and genomic deletions. This provides novel insights into solutions to problems that cannot be solved with classical 3'-end-based microarrays.

These assays provide a detailed view of the transcriptome, facilitating the fastest path to actionable results. Available for human, mouse, and rat models, they allow transcriptional research scientists to quickly and easily generate high-fidelity biomarker signatures.

Ⅲ. Copy Number Analysis Using Microarrays

Microarrays are the platform of choice for detecting DNA structural variations (SVs) such as chromosomal insertions, duplications, and deletions. In addition to these copy number variations (CNVs), genome-wide arrays that cover both polymorphic (SNP) and non-polymorphic regions can additionally detect chromosomal imbalance and allelic imbalance in long continuous stretches of homozygosity (LCSH).

Ⅳ. Human Genotyping Using Microarray Chips

Genotyping Solutions offers a uniquely flexible choice of customizable or predesigned arrays with imputation designs that cover a wider range of populations than any other technology. Proprietary photolithographic arrays ensure fidelity and consistency across production lots, keeping designs available for as long as users require them. All arrays have access to fill-optimized designs that intergrate GWAS, replication, and fine-mapping whin a single study. As the only genotyping solution offering more than 10 million fully annotated markers-validated by conventional molecular biology laboratories-this platform enables researchers to easily and cost-effectively develop arrays optimized for their application design.

Ⅴ. Microarray and GBS Solutions for Agricultural Genomics

The Agrigenomics Genotyping Solution provides breeders and researchers with powerful genotyping tools and a flexible range to validate, identify, and screen for complex genetic traits in plants and animals. It's robust, reproducible, and scalable product portfolio that facilitates marker-assisted selection, genome-wide association studies, quantitative trait locus analysis, and parent-offspring relationship verification-accelerating the advancement of genomic selection programs.

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